Formulation And Evaluation Of Berberine Hydrochloride Film Coated Tablet
نویسندگان
چکیده
The purpose of the present study was to formulate and evaluate Berberine HCl Film coated tablet. Preformulation studies API were done. film tablets have advantages over conventional oral dosage forms, tablet also influences release drug after compression. coating help in making with good taste masking properties excellent mechanical strength. It revealed that cellulosic materials unable resist compression forces whereas hydroxypropyl methyl cellulose co-polymers forces. Furthermore, aqueous dispersions showed high flexibility as thereby providing resistance from destructive compressional characteristics done per Pharmacopeial specifications. drugs excipients compatibility carried out by FT-IR spectroscopy. Various pre-compressional parameters like bulk density, tapped compressibility index Hausner’s ratio post-compressional weight variation, thickness, hardness, friability, disintegration time studied. spectra elucidate there no interaction between Drug excipients. In order achieve best optimized product, five different formulations developed using diluents, binder, glidant, lubricant, concentrations super-disintegrant. prepared wet granulation method. Optimization it found profile be super-disintegrant is Crospovidone Enhance DT. Protectab HP-1 on tablets. In-vitro medium 6.8 pH Phosphate buffer. formulation F-5 better selected an formulation.
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ژورنال
عنوان ژورنال: Journal of Pharmaceutical Negative Results
سال: 2023
ISSN: ['0976-9234', '2229-7723']
DOI: https://doi.org/10.47750/pnr.2023.14.02.403